IB-analyzer tutorial

To organise all of the preclinical data contained in the IB and reduce the risk of overlooking important results, CHDR’s IB-Derisk tool arranges all preclinical experiments in a convenient table according to the maximal concentration (Cmax) achieved after administration of a single weight-corrected dose. For most species used in preclinical research, Cmax is determined from pharmacokinetics experiments. The Cmax value is then used to rank all of the findings with respect to pharmacological effects in various species. The outcomes are then colour-coded, providing a visual overview of the compound’s intended and/or unintended effects. These colour codes provide additional structure and can help reveal irregularities. Importantly, this visualisation also helps the investigator detect possible risks that might otherwise go unnoticed in the IB.